A Pakistan International Airlines Airbus A320 passenger jet flying from Lahore has crashed in a densely populated residential area of Karachi.
Flight PK8303, carrying 91 passengers and eight crew, crashed on approach to the busy Jinnah International Airport.
The provincial health minister said at least 11 people had died, but a far higher toll is feared. Reports say at least one passenger survived the crash.
Thick black smoke rose from a scene of devastation in the Model Colony area.
TV footage showed rescue crews combing through debris strewn across the streets of the district – 3.2km (two miles) north-east of the airport – where a number of houses have been destroyed.
The plane had lost contact with air traffic control just after 14:30 local time (09:30 GMT), an airline spokesman said.