Based on an autopsy report, “Friends” actor Matthew Perry died as a consequence of “acute effects of ketamine” and drowning. Ketamines are generally used in hospitals as anesthetics, but research has shown that they may also be quite effective in treating severe depression, anxiety, and suicidal thoughts. It can be taken illicitly to get a strong high and dissociative effects as a club drug.

Per the Los Angeles Medical Examiner’s Office report, Perry’s blood tested positive for ketamine, which is used to treat depression and anxiety. “At the high levels of ketamine found in his postmortem blood specimens, the main lethal effects would be from both cardiovascular overstimulation and respiratory depression,” according to the paper. According to the report, the death was declared an accident.

On October 28, Perry was discovered face-down in the pool of his Pacific Palisades residence. Authorities stated at the time that there was no foul play involved. The actor, 54, was discovered “unconscious in a stand-alone jacuzzi,” a representative for the Los Angeles Fire Department told CNN at the time.

Perry was “reported to be receiving ketamine infusion therapy for depression and anxiety,” according to the autopsy report.

According to the paper, ketamine has medicinal and surgical applications as an anesthetic and is also renowned as a recreational drug “primarily due to its’dissociative’ nature, indicating a disconnection of mind and body.” It can also produce hallucinating and psychedelic effects for a brief period of time.” Based on the autopsy, Perry’s last known treatment was a week and a half before his death; long beyond the period it would still be in his system following the therapy.

Perry’s autopsy report’s investigation summary reveals that his live-in aide discovered his unconscious corpse in the pool after returning from doing errands. According to the investigation, “the assistant jumped into the pool, moved the decedent to the steps in a sitting position, and dialed 911.”

According to the study, “the assistant did not report any recent illnesses, complaints, drinking, or drug abuse.”

“Because of the possibility of submersion into the pool as he lapsed into unconsciousness,” the autopsy notes that drowning is thought to have played a role in Perry’s demise. This month, Jennifer Aniston, who costarred with him on “Friends,” revealed that she spoke with Perry the day before he passed away and that he “was happy.” She stated, “Funny Matty, I was actually texting with him that morning,” in an interview with Variety. He didn’t feel any discomfort. He wasn’t having any difficulty.

He was content. He was in good health, she said. “He was no longer smoking.” He was becoming more physically fit.

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